Mastocytosis represents a group of rare related disorders, with potential for unpredictably heighetned mast cell activity in response to the stress of labour, indicating importance in a management of such condition during pregnancy. We present a case of 34-year-old Caucasian, with remarkable past medical and obstetric history in whom early postpartal period was complicated with anaphylaxis. With this case, we attempt to add to the limited literature demonstrating that the life threatening condition in women with mastocytosis can occur in puerperium after the asymptomatic course of pregnancy and uneventful delivery.