Abstrakt

Physiological pregnancy is accompanied by changes in local and systemic  coagulation and fibrinolysis. Haemostasis  interferes with the implantation of the blastocyst and  placentation. Maintain optimal blood flow placenta, ensures prompt and adequate clotting  during the labour. Many coagulation proteins are expressed early in embryonic development and play roles outside of coagulation in cells  proliferation and differentiation. Mechanism regulating haemostasis within the placenta remain poorly understood. Disorders of haemostasis are involved in peripatum hemorrhage, gestational thromboembolism and are considered a risk factor for unsuccessful reproduction and pregnancy complications.